Top Research Publications: May 2022

Note: Names in bold are faculty members in the Department of Internal Medicine.

Endocrinology, Metabolism & Diabetes

• Gorsi B, Hernandez E, Moore MB, Moriwaki M, Chow CY, Coelho E, Taylor E, Lu C, Walker A, Touraine P, Nelson LM, Cooper AR, Mardis ER, Rajkovic A, Yandell M, Welt CK. 
• Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2022 Feb 17;107(3):685-714. doi:10.1210/clinem/dgab775.PMID: 34718612

Epidemiology

• Knight SJ, Haibach JP, Hamilton AB, Whittle J, Ono SS, Butler J, Flower M, Ray CD, Pugh MJ, Zickmund SL. Veteran Engagement in Health Services Research: a Conceptual Model. J Gen Intern Med. 2022 Apr;37(Suppl 1):94-98. doi: 10.1007/s11606-021-07309-z. Epub 2022 Mar 29. PMID: 35349018; PMCID: PMC8993964.
• Heerspink HJL, Inker L, Greene T. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2022 May 26;386(21):e57. doi: 10.1056/NEJMc2118470. PMID: 35613033.
• Howard JT, Stewart IJ, Amuan M, Janak JC, Pugh MJ. Association of Traumatic Brain Injury With Mortality Among Military Veterans Serving After September 11, 2001. JAMA Netw Open. 2022 Feb 1;5(2):e2148150. doi: 10.1001/jamanetworkopen.2021.48150. PMID: 35147684; PMCID: PMC8837911.

Gastroenterology, Hepatology & Nutrition

• Peterson K, Clayton F, Qeadan F, Gorman D, Robson J, Allen-Brady K, Fang JC. Esophageal Eosinophilia Is Common Among Relatives of Eosinophilic Esophagitis Patients. Clin Gastroenterol Hepatol. 2022 May;20(5):e957-e963. doi: 10.1016/j.cgh.2020.11.023. Epub 2020 Nov 19. PMID: 33221551
• Gawron AJ, Sultan S, Glorioso TJ, Califano S, Kralovic SM, Jones M, Kirsh S, Dominitz JA. Pre-Endoscopy COVID-19 screening and SARS-CoV-2 nucleic acid amplification testing in the VA Healthcare System: Clinical practice patterns, outcomes, and relationship to procedure volume. Gastrointest Endosc. 2022 Apr 21:S0016-5107(22)00288-7. doi: 10.1016/j.gie.2022.04.018. Online ahead of print. PMID: 35461889
• Papamichael K, Jairath V, Zou G, Cohen B, Ritter T, Sands B, Siegel C, Valentine J, Smith M, Vande Casteele N, Dubinsky M, Cheifetz A. Proactive infliximab optimisation using a pharmacokinetic dashboard versus standard of care in patients with Crohn's disease: study protocol for a randomised, controlled, multicentre, open-label study (the OPTIMIZE trial). BMJ Open. 2022 Apr 1;12(4):e057656. doi: 10.1136/bmjopen-2021-057656. PMID: 35365535

Infectious Diseases

• Garbern SC, Nelson EJ, Nasrin S, Keita AM, Brintz BJ, Gainey M, Badji H, Nasrin D, Howard J, Taniuchi M, Platts-Mills JA, Kotloff KL, Haque R, Levine AC, Sow SO, Alam NH, Leung DT. External validation of a mobile clinical decision support system for diarrhea etiology prediction in children: A multicenter study in Bangladesh and Mali. Elife. 2022 Feb 9;11:e72294. doi: 10.7554/eLife.72294 https://doi.org/10.7554/eLife.72294
• Wolfe CR, Tomashek KM, Patterson TF, Gomez CA, Marconi VC, Jain MK, Yang OO, Paules CI, Palacios GMR, Grossberg R, Harkins MS, Mularski RA, Erdmann N, Sandkovsky U, Almasri E, Pineda JR, Dretler AW, Lopez de Castilla Diego, Branche AR, Park PK, Mehta AK, Short WR, McLellan SFL, Kline S, Iovine NM, El Sahly HM, Doernberg SB, Oh M, Huprikar N, Hohmann E, Kelley CF, Holodniy M, Kim ES, Sweeney DA, Finberg RW,Grimes KA, Maves RC, Ko ER, Engemann JJ, Taylor BS, Ponce PO, Larson L, Melendez DP, Seibert AM, Rouphael NG, Strebe J, Clark JL, Julian KG, Ponce de Leon A, Cardoso A, de Bono S, Atmar RL, Ganesan A, Ferreira JL, Green M. Makowski M, Bonnett T, Beresnev T, Ghazaryan V, Dempsey W, Nayak SU, Dodd LE, Beigel JH, Kalil AC, for the ACTT-4 Study Group*. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial. Lancet Respir Med 2022. Published Online. May 23, 2022. https://doi.org/10.1016/S2213-2600(22)00088-1 DOI: https://doi.org/10.1016/S2213-2600(22)00088-1 
• Sullivan DJ, Gebo KA, Shoham S, Bloch EM, Lau B,  Shenoy AG, Monsnaim GS, Gniadek TJ, Fukuta Y, Patel B, Heath SL, Levine, AD, Spivak E. Early Out Patient Treatment for Covid-19 with Convalescent Plasma. N Engl J Med 2022: 386:1700-1711 DOI: 10.1056/NEJMoa2119657

Oncology

• Agarwal N, Tangen CM, Hussain MHA, Gupta S, Plets M, Lara PN, Harzstark AL, Twardowski PW, Paller CJ, Zylla D, Zibelman MR, Levine E, Roth BJ, Goldkorn A, Vaena DA, Kohli M, Crispino T, Vogelzang NJ, Thompson IM Jr, Quinn DI. Orteronel for Metastatic Hormone-Sensitive Prostate Cancer: A Multicenter, Randomized, Open-Label Phase III Trial (SWOG-1216). J Clin Oncol. 2022 Apr 21:JCO2102517. doi: 10.1200/JCO.21.02517. Online ahead of print. PMID: 35446628.
• Guillen KP, Fujita M, Butterfield AJ, Scherer SD, Bailey MH, Chu Z, DeRose YS, Zhao L, Cortes-Sanchez E, Yang CH, Toner J, Wang G, Qiao Y, Huang X, Greenland JA, Vahrenkamp JM, Lum DH, Factor RE, Nelson EW, Matsen CB, Poretta JM, Rosenthal R, Beck AC, Buys SS, Vaklavas C, Ward JH, Jensen RL, Jones KB, Li Z, Oesterreich S, Dobrolecki LE, Pathi SS, Woo XY, Berrett KC, Wadsworth ME, Chuang JH, Lewis MT, Marth
• GT, Gertz J, Varley KE, Welm BE, Welm AL. A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.Nat Cancer. 2022 Feb;3(2):232-250. doi: 10.1038/s43018-022-00337-6. Epub 2022 Feb 24. PMID: 35221336.
• Graf RP, Fisher V, Weberpals J, Gjoerup O, Tierno MB, Huang RSP, Sayegh N, Lin DI, Raskina K, Schrock AB, Severson E, Haberberger JF, Ross JS, Creeden J, Levy MA, Alexander BM, Oxnard GR, Agarwal N. Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy by Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer. JAMA Netw Open. 2022 Mar 1;5(3):e225394. doi: 10.1001/jamanetworkopen.2022.5394. PMID: 35357449.

Rheumatology

• Sawitzke AD, Jackson CG, Carlson K, Bizien MD, Leiner M, J Reda DJ, Sindowski T, Hanrahan C, Richard G Spencer, Kwoh CK, J Lee SJ, Hose K, Robin L, Cain DW, D Taylor MD, Bangerter N, Finco M, Clegg DO. Effect of Pulsed Low-Intensity Ultrasonography on Symptom Relief and Tibiofemoral Articular Cartilage Thickness Among Veterans Affairs Enrollees With Knee Osteoarthritis: A Randomized Clinical Trial JAMA Netw Open. 2022 Mar 1;5(3):e220632. doi: 10.1001/jamanetworkopen.2022.0632 PMID: 35258579.
• Walsh JA, Magrey MN, Baraliakos X, Inui K, Weng MY, Lubrano E, van der Heijde D, Boonen A, Gensler LS, Strand V, Braun J, Hunter T, Li X, Zhu B, León L, Calderon DMS, Kiltz U. Improvement of Functioning and Health With Ixekizumab in the Treatment of Active Nonradiographic Axial Spondyloarthritis in a 52-Week, Randomized, Controlled Trial. Arthritis Care Res (Hoboken). 2022 Mar;74(3):451-460. doi: 10.1002/acr.24482 PMID: 33044756.