Top Research Publications: December 2020
Note: Names in bold are faculty members in the Department of Internal Medicine.
Cardiology
Jones TL, Tan MC, Nguyen V, Kearney KE, Maynard CC, Anderson E, Mahr C, McCabe JM. Outcome Differences in Acute vs. Acute on Chronic Heart Failure and Cardiogenic Shock. ESC Heart Failure. 2020 Mar; 7:1118-1124. doi: 10.1002/ehf2.12670.
Ko B, Drakos SG, Ibrahim H, Kang TS, Thodou A, Bonios M, Taleb I, Welt FGP. Percutaneous Mechanical Unloading Simultaneously with Reperfusion Induces Increased Myocardial Salvage in Experimental Acute Myocardial Infarction. Circulation: Heart Failure, 2020; 13. doi: 10.1161/circheartfailure.119.005893.
Liu Y, Zhou K, Li J, Agvanian S, Caldaruse A, Shaw S, Hitzeman TC, Shaw RM, Hong TT. In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium Handling Machinery and Cardiac Function. JACC: Basic to Translational Science. 2020 Jun; 5(6):561-578. doi: 10.1016/j.jacbts.2020.03.006.
Endocrinology, Metabolism & Diabetes
Lin YK, Fisher SJ, Pop-Busui R. Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies. J Diabetes Investig. 2020 Nov;11(6):1388-1402. doi: 10.1111/jdi.13290. Epub 2020 Jul 7. PMID: 32403204.
Epidemiology
Bryan MA, Smid MC, Cheng M, Fortenberry KT, Kenney A, Muniyappa B, Pendergrass D, Gordon AJ, Cochran G. Addressing opioid use disorder among rural pregnant and postpartum women: a study protocol. Addiction science & clinical practice. 2020 15(1), 33. Doi: 10.1186/s13722-020-00206-6.
Brown SM, Peltan I, Kumar N, Leither L, Webb BJ, Starr N, Grissom CK, Buckel WR, Srivastava R, Butler AM, Groat D, Haaland B, Ying J, Harris E, Johnson S, Paine R 3rd, Greene T. Hydroxychloroquine vs. Azithromycin for Hospitalized Patients with COVID-19 (HAHPS): Results of a Randomized, Active Comparator Trial. Ann Am Thorac Soc. 2020 Nov 9. doi: 10.1513/AnnalsATS.202008-940OC. Epub ahead of print. PMID: 33166179.
Sauer BC, Chen W, Xu Y, Shen J, Accortt NA, Collier DH, Cannon GW. Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis. Arthritis Research & Therapy. 2020, 22, 253. Doi: 10.1186/s13075-020-02346-1.
Gastroenterology, Hepatology & Nutrition
Gawron AJ, Kaltenbach T, Dominitz JA. The Impact of the COVID-19 Pandemic on Access to Endoscopy Procedures in the VA Healthcare System. Gastroenterology. 2020 Jul 22:S0016-5085(20)34995-7. doi: 10.1053/j.gastro.2020.07.033. PMID: 32710908.
Burke CA, Dekker E, Lynch P, Samadder NJ, Balaguer F, Hüneburg R, Burn J, Castells A, Gallinger S, Lim R, Stoffel EM, Gupta S, Henderson A, Kallenberg FG, Kanth P, Roos VH, Ginsberg GG, Sinicrope FA, Strassburg CP, Van Cutsem E, Church J, Lalloo F, Willingham FF, Wise PE, Grady WM, Ford M, Weiss JM, Gryfe R, Rustgi AK, Syngal S, Cohen A. Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis. N Engl J Med. 2020 Sep 10;383(11):1028-1039. doi: 10.1056/NEJMoa1916063. PMID: 32905675.
Dellon ES, Peterson KA, Murray JA, Falk GW, Gonsalves N, Chehade M, Genta RM, Leung J, Khoury P, Klion AD, Hazan S, Vaezi M, Bledsoe AC, Durrani SR, Wang C, Shaw C, Chang AT, Singh B, Kamboj AP, Rasmussen HS, Rothenberg ME, Hirano I. Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis. N Engl J Med. 2020 Oct 22;383(17):1624-1634. doi: 10.1056/NEJMoa2012047. PMID: 33085861.
Geriatrics
Rapp SR, Gaussoin SA, Sachs BC, Chelune G, Supiano MA, Lerner AJ, Wadley VG, Wilson VM, Fine LJ, Whittle JC, Auchus AP, Beddhu S, Berlowitz DR, Bress AP, Johnson KC, Krousel-Wood M, Martindale-Adams J, Miller EC, Rifkin DE, Snyder JK, Tamariz L, Wolfgram DF, Cleveland ML, Yang M, Nichols LO, Bryan RN, Reboussin DM, Williamson JD, Pajewski NM. Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial. The Lancet Neurology. 2020 Nov 10(11):899-907. doi: 10.1016/S1474-4422(20)30319-7.
Hematology & Hematologic Malignancies
Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O’Connell RM, Rondina MT, Campbell RC, Bray PF. miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood 136: 1702–1703, 2020. doi: 10.1182/blood.2020007381. PMID: 32844999.
Gordeuk VR, Miasnikova GY, Sergueeva AJ, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal JT. Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit. Haematologica; 2020 Mar;105(3):e87-e90. PMID: 31289208.
Infectious Diseases
Sutton JD, Stevens VW, Chang NN, Khader K, Timbrook TT, Spivak ES. Oral β-Lactam Antibiotics vs Fluoroquinolones or Trimethoprim-Sulfamethoxazole for Definitive Treatment of Enterobacterales Bacteremia From a Urine Source. JAMA Nerw Open. 2020 Oct 1;3(10):e2020166. doi: 10.1001/jamanetworkopen.2020.20166. PMID: 33030555.
Shakir SM, Barker AP, Hillyard DR, Gilmore N, Barrett JW, Orlandi RR, Hanson KE. Combined Self-collected Anterior Nasal and Oropharyngeal Specimens versus Provider-collected Nasopharyngeal Swabs for the Detection of SARS-CoV-2. Journal of Clinical Microbiology 2020 Oct 21; JCM.02291-20. doi:10.1128/JCM.02291-20. PMID: 33087437.
Trivedi S, Labuz D, Anderson CP, Araujo CV, Blair A, Middleton EA, Jensen O, Tran A, Mulvey MA, Campbell RA, Hale JS, Rondina MT, Leung DT. Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. Elife. 2020 Nov 9; 9:e55615. doi: 10.7554/eLife.55615. Online ahead of print. PMID: 33164745.
Oncology
Vaklavas C, Roberts BS, Varley KE, Lin NU, Liu MC, Rugo HS, Puhalla S, Nanda R, Storniolo AM, Carey LA, Saleh MN, Li Y, Delossantos JF, Grizzle WE, LoBuglio AF, Myers RM, Forero-Torres A. TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancer. Breast Cancer Res. 2020; 22: 22. PMID: 32070401.
Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, Blakely CM, Seto T, Cho BC, Tosi D, Besse B, Chawla SP, Bazhenova L, Krauss JC, Chae YK, Barve M, Garrido-Laguna I, Liu SV, Conkling P, John T, Fakih M, Sigal D, Loong HH, Buchschacher GL Jr, Garrido P, Nieva J, Steuer C, Overbeck TR, Bowles DW, Fox E, Riehl T, Chow-Maneval E, Simmons B, Cui N, Johnson A, Eng S, Wilson TR, Demetri GD; trial investigators. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials. Lancet Oncol. 2020 Feb;21(2):271-282. doi: 10.1016/S1470-2045(19)30691-6. Epub 2019 Dec 11. PMID: 31838007.
Nevala-Plagemann C, Hidalgo M, Garrido-Laguna I. From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer. Nat Rev Clin Oncol. 2020 Feb;17(2):108-123. doi: 10.1038/s41571-019-0281-6. Epub 2019 Nov 8. PMID: 31705130.
Rheumatology
Aranow C, Cush J, Bolster MB, Striebich CC, Dall'era M, Mackay M, Olech E, Frech T, Box J, Keating R, Wasko MC, St Clair W, Kivitz A, Huang W, Ricketts P, Welch B, Callahan S, Spychala M, Boyle K, York K, Keyes-Elstein L, Goldmuntz E, Diamond B, Davidson A. A double-blind, placebo-controlled, phase II, randomized study of lovastatin therapy in the treatment of mildly active rheumatoid arthritis. Rheumatology (Oxford). 2020 Jul 1;59(7):1505-1513. PMID: 31628482.